176212595250 Essays - Beer Judge Certification Program, Homebrewing

176212595250 High Desert Brewers " Brew News " February 2016 00 High Desert Brewers " Brew News " February 2016 -47625809625 Greetings Members and Guests, We hope you are surviving, the cold and snowy winter we are experiencing this yearSpring is on it's way Some new additions for the Club: Eric has put together a new web site highdesertbrewers.wordpress.com that we hope will increase our ability to communicate with the Membership, Our Facebook page also has a new look as well and we are working to respond to the request from membership. Contact us with your requests , HYPERLINK "mailto:[emailprotected]" [emailprotected] [emailprotected] Valentines Party Feb. 14 th Keefers Island Restaurant- Bob and Kathy Beckwith have gone to great lengths to make this annual event a success , We hope that you can make it. We are also hoping to update our Membership contact information at that time as well. Summer Picnic update- we have been looking for a good place to have a good old fashioned Family Picnic and should have that location finalized soon. We want to make sure there is a room for fun and games for adults and children. Keep in touch and we will let you know the details Chuckars Ball game day: Member, Aubrey Wieber has stepped up to the "plate" and has volunteered to be the lead person on this annual Club Event. This is one you sure don't want to miss, the Club will pay you admission and also provide you with tickets for a hot dog and two (2) ice cold beers, and as usual we will have some Swag to share with the Members.We will be announcing the time and date in the near future. Possible Club Golf outing: Bob Beckwith is pursuing the possibility of having a Golf Tournament in the fall, we will keep you informed as detail become available Eastern Idaho State Fair- Homebrew Beer Wine competition 2016 This event entering it's 21 st . year has been registered with the BJCP and the AHA and information can be obtained at the HDBA web site- highdesertbrewers.wordpress.com Thanks to all the Members and let's all work to make the Club stronger in 2016 CHEERS !!! 0 Greetings Members and Guests, We hope you are surviving, the cold and snowy winter we are experiencing this yearSpring is on it's way Some new additions for the Club: Eric has put together a new web site highdesertbrewers.wordpress.com that we hope will increase our ability to communicate with the Membership, Our Facebook page also has a new look as well and we are working to respond to the request from membership. Contact us with your requests , HYPERLINK "mailto:[emailprotected]" [emailprotected] [emailprotected] Valentines Party Feb. 14 th Keefers Island Restaurant- Bob and Kathy Beckwith have gone to great lengths to make this annual event a success , We hope that you can make it. We are also hoping to update our Membership contact information at that time as well. Summer Picnic update- we have been looking for a good place to have a good old fashioned Family Picnic and should have that location finalized soon. We want to make sure there is a room for fun and games for adults and children. Keep in touch and we will let you know the details Chuckars Ball game day: Member, Aubrey Wieber has stepped up to the "plate" and has volunteered to be the lead person on this annual Club Event. This is one you sure don't want to miss, the Club will pay you admission and also provide you with tickets for a hot dog and two (2) ice cold beers, and as usual we will have some Swag to share with the Members.We will be announcing the time and date in the near future. Possible Club Golf outing: Bob Beckwith is pursuing the possibility of having a Golf Tournament in the fall, we will keep you informed as detail become available Eastern Idaho State Fair- Homebrew Beer Wine competition 2016 This event entering it's 21 st . year has been registered with the BJCP and the AHA and information can be obtained at the HDBA web site- highdesertbrewers.wordpress.com Thanks to all the Members

Wringhim chararcter analysis essays

Wringhim chararcter analysis essays James Hoggs classic novel, The Private Memoirs and Confessions of a Justified Sinner, portrays the fictional story of Robert Wringhim, a strong Calvinist who justifies murder by quickening the inevitable. Robert commits infamous acts of evil, believing that these murderous actions glorify God by annihilating sinners not chosen to be saved. I believe that a combination of factors involving both nurture and nature shape Wringhim into the suffering creature that he becomes. The greatest of these factors include Paranoia Schizophrenia, Multiple Personality Disorder, and the rejection of society. To my limited medical knowledge, I understand Wringhim to suffer from a severe case of Paranoia Schizophrenia among other forms of mental illnesses. There is evidence for this theory in the novel. For example, it is typical for victims of this medical condition to have an immense fear that literally controls their life. In the early pages of the book, Wringhim discusses this paranoid fear which consumes his life. My heart quakes with terror, when I thought of being still living in a state of reprobation, subjected to the awful issues of death, judgment, and eternal misery...( Hobbes 118). This fear of death, judgment and eternal misery controls him and becomes all he thinks about. He goes on to describe that he prays three times a day and seven times on the Sabbath to cope with this fear of damnation. However, even though Wringhim is obsessed with the security of his salvation earlier in the novel, this fear appears to diminish by an overwhelming sense of security that he is elected to be saved from the eternal flames fire, after his father bargains with God for Robert s soul (130). Although there is little evidence to support this theory, it is not unintelligent for one to believe that Wringhims original fear of eternal damnation persists throughout his lifetime, even after he realize...

Discourse Analyse of the Simpsons Essay Example | Topics and Well Written Essays - 500 words

Discourse Analyse of the Simpsons - Essay Example 1. Why does everything have to be a movie? 2. The Simpsons has been tooling along for 18 years now as a TV show 3. and genuine cultural institution 4. and even if its quality has dipped in the last few years, 5. it remains ideally consumed in half-hour increments, perhaps with the occasional extra-long episode. 6. The adventures of the titular family 7. and the dozens of eccentric characters who inhabit Springfield are generally fast-paced 8. and densely packed with jokes, 9. with absurd plots that would fall apart 10. if stretched beyond sitcom length. 11. That’s not a flaw; 12. it’s a perfect recipe for a good TV show. 13. But now we have The Simpsons Movie, a feature-length version of the show that has some snazzier animation 14. but otherwise amounts to a decent oversized episode. 15. For dedicated fans, especially those who remain regular viewers in the show’s later years, this will probably be enough.

Has there been a change in women's rights in the last 10 years in Iran Essay

Has there been a change in women's rights in the last 10 years in Iran and Afghanistan Why or why not - Essay Example Women were even not allowed to attain social forums or talk shows throughout the 20th century. Women employment was not accepted legally and voting rights were also not given to the women of Afghanistan. The trend was also common in other countries of the Middle East, such as Iran. The Iranian women were exempted from social rights like education, marriage, divorce, sports and health rights. The Iranian women were also not given reproduction rights or abortion rights. According to the Iranian law, birth rights and family planning were decided by the males of the society. From the 19th century and throughout the 20th century, Afghan rulers made several attempts to reduce the restrictions imposed on women. Most of the attempts towards the change of women rights were unsuccessful but some of the changes were incorporated successfully, related to health and education. Similarly, the Iranian women played significant role during the Persian Constitutional Revolution for betterment of their social positions and their fight for betterment of women in the society still continues. In the 21st century it has been observed that women of Afghanistan and Iran are allowed to attain education by going to schools and colleges and they are also allowed to get employment. In the later part of 20th century, it has also been observed that Persian women are allowed to take part in journalism courses, which is a positive significance towards the country’s development. This assignment highlights the important changes in women rights that occurred between 2003 and 2014 along with the reasons behind the transformations that happened. The assignment is based on observations collected from important articles. It also contains information provided by theorists and researchers towards the idea of women empowerment and their rights. The analysis is done based on observations collected from historical progresses to the current situations. It is clear that the women rights in

Domestic Crime Rate and the Right to Bear Arms Research Paper

Domestic Crime Rate and the Right to Bear Arms - Research Paper Example Furthermore, in Unites States v Cruikshank and Presser v Illinois, the court held that the Second Amendment restricted only the federal government. Several of the state laws relating to the ownership of guns have been upheld on the basis of these decisions (Vernick , Rutkow , Webster , & Teret , 2011, p. 2022). Main Body The Gun Control Act of 1968, provides that no convicted felon should possess firearms. This has been amended by the Lautenberg Amendment, which extends the preclusion of firearms possession to individuals convicted of misdemeanor crimes of domestic violence. This amendment was aimed at preventing the convicted perpetrators of domestic violence from carrying firearms (Guns and domestic violence, 2008, p. B4). In addition, armed domestic abusers pose a very great risk. In fact, around 67% of the females who are killed by firearms have been shot by their intimate partner. The weapon of choice in intimate partner homicide is the firearm. There is a five – fold inc rease of risk of homicide for females, when firearms are present in the home. These are indeed disquieting figures, and such data induced Congress to amend the Gun Control Act on several occasions. For instance, in 1994, an amendment was made to this Act, which precluded any individual subject to a domestic violence protective order, from possessing a firearm. This was followed, in the year 1996, by the Lautenberg Amendment, which prohibited any individual convicted of a misdemeanor crime of domestic violence from possessing a firearm (Wilkinson & Meisner, 2011). However, in the absence of the necessary level of regulation and supervision over entities that could make substantial profits by evading the laws, an effective gun control mechanism cannot be implemented. To its discredit, Congress... The Second Amendment Rights to bear firearms is not an exclusive right granted by the constitution. It does have limitations to provide a restraint on bearing firearms under certain circumstances. The federal law and the laws of many states do not permit an individual who has been convicted of a misdemeanor of domestic violence or who is under a restraining order to possess a firearm. However, there are several shortcomings, when it comes to implementing these laws. There is considerable scope for improving the situation, and there should be proactive initiatives to confiscate weapons from the prohibited intimate partner violence offenders. All the same, laws that preclude the possession of firearms by such individuals, actually bring down instances of domestic homicide. Reckless act of violence could be significantly reduced by having tougher gun control law in place. It would indeed be very helpful, if a license had to be obtained by every purchaser of a handgun. In addition, the l icense should be provided only after the purchaser had completed a course on the responsible use of firearms.

Current Status of Gene Therapy Research

Current Status of Gene Therapy Research Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, its the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is a technique for correcting defective genes responsible for disease development. Researchers may use one of several approaches for correcting faulty genes: A normal gene may be inserted into a nonspecific location within the genome to replace a nonfunctional gene. This approach is most common. An abnormal gene could be swapped for a normal gene through homologous recombination. The abnormal gene could be repaired through selective reverse mutation, which returns the gene to its normal function. The regulation (the degree to which a gene is turned on or off) of a particular gene could be altered. How does gene therapy work? In most gene therapy studies, a normal gene is inserted into the genome to replace an abnormal, disease-causing gene. A carrier molecule called a vector must be used to deliver the therapeutic gene to the patients target cells. Currently, the most common vector is a virus that has been genetically altered to carry normal human DNA. Viruses have evolved a way of encapsulating and delivering their genes to human cells in a pathogenic manner. Scientists have tried to take advantage of this capability and manipulate the virus genome to remove disease-causing genes and insert therapeutic genes. Target cells such as the patients liver or lung cells are infected with the viral vector. The vector then unloads its genetic material containing the therapeutic human gene into the target cell. The generation of a functional protein product from the therapeutic gene restores the target cell to a normal state. See adiagram  depicting this process. Some of the different types of viruses used as gene therapy vectors: Retroviruses   A class of viruses that can create double-stranded DNA copies of their RNA genomes. These copies of its genome can be integrated into the chromosomes of host cells. Human immunodeficiency virus (HIV) is a retrovirus. Adenoviruses   A class of viruses with double-stranded DNA genomes that cause respiratory, intestinal, and eye infections in humans. The virus that causes the common cold is an adenovirus. Adeno-associated viruses   A class of small, single-stranded DNA viruses that can insert their genetic material at a specific site on chromosome 19. Herpes simplex viruses   A class of double-stranded DNA viruses that infect a particular cell type, neurons. Herpes simplex virus type 1 is a common human pathogen that causes cold sores. Besides virus-mediated gene-delivery systems, there are several nonviral options for gene delivery. The simplest method is the direct introduction of therapeutic DNA into target cells. This approach is limited in its application because it can be used only with certain tissues and requires large amounts of DNA. Another nonviral approach involves the creation of an artificial lipid sphere with an aqueous core. This liposome, which carries the therapeutic DNA, is capable of passing the DNA through the target cells membrane. Therapeutic DNA also can get inside target cells by chemically linking the DNA to a molecule that will bind to special cell receptors. Once bound to these receptors, the therapeutic DNA constructs are engulfed by the cell membrane and passed into the interior of the target cell. This delivery system tends to be less effective than other options. Researchers also are experimenting with introducing a 47th (artificial human) chromosome into target cells. This chromosome would exist autonomously alongside the standard 46 not affecting their workings or causing any mutations. It would be a large vector capable of carrying substantial amounts of genetic code, and scientists anticipate that, because of its construction and autonomy, the bodys immune systems would not attack it. A problem with this potential method is the difficulty in delivering such a large molecule to the nucleus of a target cell. What is the current status of gene therapy research? The Food and Drug Administration (FDA) has not yet approved any human gene therapy product for sale. Current gene therapy is experimental and has not proven very successful in clinical trials. Little progress has been made since the first gene therapy clinical trial began in 1990. In 1999, gene therapy suffered a major setback with the death of 18-year-old Jesse Gelsinger. Jesse was participating in a gene therapy trial for ornithine transcarboxylase deficiency (OTCD). He died from multiple organ failures 4 days after starting the treatment. His death is believed to have been triggered by a severe immune response to the adenovirus carrier. Another major blow came in January 2003, when the FDA placed a temporary halt on all gene therapy trials using retroviral vectors in blood stem cells. FDA took this action after it learned that a second child treated in a French gene therapy trial had developed a leukemia-like condition. Both this child and another who had developed a similar condition in August 2002 had been successfully treated by gene therapy for X-linked severe combined immunodeficiency disease (X-SCID), also known as bubble baby syndrome. FDAs Biological Response Modifiers Advisory Committee (BRMAC) met at the end of February 2003 to discuss possible measures that could allow a number of retroviral gene therapy trials for treatment of life-threatening diseases to proceed with appropriate safeguards. In April of 2003 the FDA eased the ban on gene therapy trials using retroviral vectors in blood stem cells. What factors have kept gene therapy from becoming an effective treatment for genetic disease? Short-lived nature of gene therapy   Before gene therapy can become a permanent cure for any condition, the therapeutic DNA introduced into target cells must remain functional and the cells containing the therapeutic DNA must be long-lived and stable. Problems with integrating therapeutic DNA into the genome and the rapidly dividing nature of many cells prevent gene therapy from achieving any long-term benefits. Patients will have to undergo multiple rounds of gene therapy. Immune response   Anytime a foreign object is introduced into human tissues, the immune system is designed to attack the invader. The risk of stimulating the immune system in a way that reduces gene therapy effectiveness is always a potential risk. Furthermore, the immune systems enhanced response to invaders it has seen before makes it difficult for gene therapy to be repeated in patients. Problems with viral vectors   Viruses, while the carrier of choice in most gene therapy studies, present a variety of potential problems to the patient toxicity, immune and inflammatory responses, and gene control and targeting issues. In addition, there is always the fear that the viral vector, once inside the patient, may recover its ability to cause disease. Multigene disorders   Conditions or disorders that arise from mutations in a single gene are the best candidates for gene therapy. Unfortunately, some the most commonly occurring disorders, such as heart disease, high blood pressure, Alzheimers disease, arthritis, and diabetes, are caused by the combined effects of variations in many genes. Multigene or multifactorial disorders such as these would be especially difficult to treat effectively using gene therapy. For more information on different types of genetic disease, see  Genetic Disease Information. What are some recent developments in gene therapy research? Nanotechnology + gene therapy yields treatment to torpedo cancer. March, 2009. The School of Pharmacy in London is testing a treatment in mice, which delivers genes wrapped in nanoparticles to cancer cells to target and destroy hard-to-reach cancer cells. Read  BBC article. Results of worlds first gene therapy for inherited blindness show sight improvement. 28 April 2008. UK researchers from the UCL Institute of Ophthalmology and Moorfields Eye Hospital NIHR Biomedical Research Centre have announced results from the worlds first clinical trial to test a revolutionary gene therapy treatment for a type of inherited blindness. The results, published today in the New England Journal of Medicine, show that the experimental treatment is safe and can improve sight. The findings are a landmark for gene therapy technology and could have a significant impact on future treatments for eye disease. Read  Press Release. Previous information on this trial (May 1, 2007): A team of British doctors from Moorfields Eye Hospital and University College in London conduct first human gene therapy trials to treat Lebers congenital amaurosis, a type of inherited childhood blindness caused by a single abnormal gene. The procedure has already been successful at restoring vision for dogs. This is the first trial to use gene therapy in an operation to treat blindness in humans. See  Doctors Test Gene Therapy to Treat Blindness  at www.reuters.com.   A combination of two tumor suppressing genes delivered in lipid-based nanoparticles drastically reduces the number and size of human lung cancer tumors in mice during trials conducted by researchers from The University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center. See  Dual Gene Therapy Suppresses Lung Cancer in Preclinical Test  at www.newswise.com (January 11, 2007). Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, successfully reengineer immune cells, called lymphocytes, to target and attack cancer cells in patients with advanced metastatic melanoma. This is the first time that gene therapy is used to successfully treat cancer in humans. See  New Method of Gene Therapy Alters Immune Cells for Treatment of Advanced Melanoma  at www.cancer.gov (August 30, 2006).   Gene therapy is effectively used to treat two adult patients for a disease affecting nonlymphocytic white blood cells called myeloid cells. Myeloid disorders are common and include a variety of bone marrow failure syndromes, such as acute myeloid leukemia. The study is the first to show that gene therapy can cure diseases of the myeloid system. See  Gene Therapy Appears to Cure Myeloid Blood Diseases In Groundbreaking International Studyat www.cincinnatichildrens.org (March 31, 2006).   Gene Therapy cures deafness in guinea pigs. Each animal had been deafened by destruction of the hair cells in the cochlea that translate sound vibrations into nerve signals. A gene, called  Atoh1,  which stimulates the hair cells growth, was delivered to the cochlea by an adenovirus. The genes triggered re-growth of the hair cells and many of the animals regained up to 80% of their original hearing thresholds. This study, which many pave the way to human trials of the gene, is the first to show that gene therapy can repair deafness in animals. See  Gene Therapy is First Deafness Cure  at NewScientist.com (February 11, 2005). University of California, Los Angeles, research team gets genes into the brain using liposomes coated in a polymer call polyethylene glycol (PEG). The transfer of genes into the brain is a significant achievement because viral vectors are too big to get across the blood-brain barrier. This method has potential for treating Parkinsons disease. See  Undercover Genes Slip into the Brain  at NewScientist.com (March 20, 2003). RNA interference or gene silencing may be a new way to treat Huntingtons. Short pieces of double-stranded RNA (short, interfering RNAs or siRNAs) are used by cells to degrade RNA of a particular sequence. If a siRNA is designed to match the RNA copied from a faulty gene, then the abnormal protein product of that gene will not be produced. See  Gene Therapy May Switch off Huntingtons  at NewScientist.com (March 13, 2003). New gene therapy approach repairs errors in messenger RNA derived from defective genes. Technique has potential to treat the blood disorder thalassaemia, cystic fibrosis, and some cancers. See  Subtle Gene Therapy Tackles Blood Disorder  at NewScientist.com (October 11, 2002). Gene therapy for treating children with X-SCID (sever combined immunodeficiency) or the bubble boy disease is stopped in France when the treatment causes leukemia in one of the patients. See  Miracle Gene Therapy Trial Halted  at NewScientist.com (October 3, 2002). Researchers at Case Western Reserve University and Copernicus Therapeutics are able to create tiny liposomes 25 nanometers across that can carry therapeutic DNA through pores in the nuclear membrane. See  DNA Nanoballs Boost Gene Therapy  at NewScientist.com (May 12, 2002).   Sickle cell is successfully treated in mice. See  Murine Gene Therapy Corrects Symptoms of Sickle Cell Disease  from March 18, 2002, issue of  The Scientist. What are some of the ethical considerations for using gene therapy? Some Questions to Consider What is normal and what is a disability or disorder, and who decides?   Are disabilities diseases? Do they need to be cured or prevented?   Does searching for a cure demean the lives of individuals presently affected by disabilities?   Is somatic gene therapy (which is done in the adult cells of persons known to have the disease) more or less ethical than germline gene therapy (which is done in egg and sperm cells and prevents the trait from being passed on to further generations)? In cases of somatic gene therapy, the procedure may have to be repeated in future generations.   Preliminary attempts at gene therapy are exorbitantly expensive. Who will have access to these therapies? Who will pay for their use?

Software Piracy Essay -- Illegal Computer Software Program Distributio

Software Piracy Software piracy is the illegal reproduction and distribution of software applications, whether it is for personal use or business. In society today, Internet users are obtaining millions of dollars in software illegally. Piracy includes the illegal copying of programs, counterfeiting and distributing software, and even sharing a program with a friend. Software has become such an important productivity tool, the illegal copying and distribution of software piracy persists globally. In fact, in the United States is one in four software programs that is unlicensed. According to the Business Software Alliance (BSA), more than 800,000 web sites illegally sell or distribute software (Microsoft.com). There are many types of software piracy such as uploading and downloading, softlifting, counterfeiting, OEM bundling, hard disk loading and renting. By having familiarity with them can protect you from any connection. Softlifting is purchasing a licensed copy of software and uploading it on several computers against the license terms. Some examples of softlifting are sharing software with friends, co-workers and others. Uploading and downloading is another form of piracy, such as when making unauthorized copies of copyrighted software available to end users connected by a modem to online service providers and or the Internet. Another one is software counterfeiting which is illegal duplicating and selling copyrighted software and a form designed to make it appear legitimate. OEM bundling is selling stand alone software that was intended to be bundled with specific accompanying hardware. Hard disk loading is installing unauthorized copies of software onto the hard disks of personal com puters, often as an incentive for th... ...t the economic implications of software piracy and software copyrights. Other analysts feel that copyright enforcement should be increased by implementing more efforts to prosecute pirates ( Parsons 165). Survey about Software Piracy Survey questions on Software Piracy YES NO 1. Do you know what software piracy actually is? 15 10 2. Do you know the negative effects of software piracy? 8 12 3. Do you even care about software piracy? 16 9 4. Do you feel that the media discusses the issue of software piracy? 7 13 Works Cited www.microsoft.com www.aladdin.com Computer Concepts. New Perspectives. June Parsons. Course Technology. 5 Feb 2003.